Description
Everolimus belongs to the anti-neoplastic agent; it comes under mTOR kinase inhibitor (single transduction inhibitor). Everolimus is an immunosuppressive macrolide.
Indication
Primarily Everolimus tablets indicated for the treatment :
kidney carcinoma, Breast carcinoma, Brain carcinoma.
Everolimus is also indicated in various advanced stage cancer in stomach, intestines or pancreas.
Dosage Regimen
In breast cancer, renal cell cancer, pancreatic cancer, Neuroendocrine cancer:The prescribed dosage is 10mg should be taken as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Everolimus as a single dose. is 4.5mg/m2 given orally
In pediatric:
The pediatric dosage of Everolimus as a single dose in the brain or intracranial tumor is 4.5mg/m2 should be given orally.
Drug Profile
Everolimus consist of an active ingredient known as Everolimus which is intruded with the of cancer cell and a process is slowing down. Everolimus tablets is not a curable medication, which helps to slow their spreading into the body.
Mechanism
Everolimus is an inhibitor of mTOR, joins at high compatibility to FK506 binding protein 12, via producing drug complex that inhibits the production of mTOR.
Side Effects
Hypersensitivity reactions, Lymphomas & other malignancy, Serious infections, Kidney graft thrombosis, Hepatic artery thrombosis, Nephrotoxicity, Hyperlipemia, Angioedema, Interstitial lung disease, Thrombocytopenia, Male infertility, Proteinuria, New commencement of diabetes.
Drug-Drug interaction
Everolimus interaction with a strong inhibitor of CYP3A4, or P-gp, cause reducing the efflux of Everolimus and high plasma concentration of Everolimus. Interaction of Everolimus with strong CYP3A4 inducers will be increasing the disclosure of Everolimus.
Combination of Everolimus with cyclosporine will be increasing the AUC level of Everolimus frequently. Combination ketoconazole with Everolimus tablet or other CYP3A4 inhibitors will be increasing the plasma concentration and AUC of Everolimus.
Pregnancy and lactation
Pregnancy category of Everolimus In patients Everolimus is used only after knowing the benefits to the mother exceed the risk to the s. Breastfeeding should not be suggested
Storage and handling
Everolimus tablet store at 25°C Store the medicine away from moisture, heat, and light.
Missed Dose
In case of a missed dose, patients must consult with a medical practitioner and follow the instructions given by them. thereby missed dose should be avoided and follow the regular dosing schedule.
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