Indication of Evertor
Primarily Evertor tablets indicated for the treatment :
- kidney carcinoma
- Breast carcinoma
- Brain carcinoma
Everolimus is also indicated in various advanced stage cancer in stomach, intestines or pancreas.
Dosage regimen of Evertor
In breast cancer, renal cell cancer, pancreatic cancer, Neuroendocrine cancer:
The prescribed dosage is 10mg should be taken as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Evertor as a single dose. is 4.5mg/m2 given orally.
In pediatric:
The pediatric dosage of Evertor as a single dose in the brain or intracranial tumor is 4.5mg/m2 should be given orally.
Mechanism
Everolimus is an inhibitor of mTOR, joins at high compatibility to FK506 binding protein 12, via producing drug complex that inhibits the production of mTOR. This inhibition reduces the activity of effectors downstream, which may lead to stoppage of cell progression from G1 into S phase, Finally causes cell growth arrest and apoptosis.
Side Effects
Hypersensitivity reactions, Lymphomas & other malignancy, Serious infections, Kidney graft thrombosis, Hepatic artery thrombosis, Nephrotoxicity, Hyperlipemia, Angioedema, Interstitial lung disease, Thrombocytopenia, Male infertility, Proteinuria, New commencement of diabetes.
Drug-Drug interaction
Evertor interaction with a strong inhibitor of CYP3A4, or P-gp, cause reducing the efflux of Everolimus and high plasma concentration of Everolimus. Interaction of Evertor with strong CYP3A4 inducers will be increasing the disclosure of Everolimus. Combination of Evertor with cyclosporine will increase the AUC level of Everolimus frequently.
Contraindication
If patients are contraindicated to the components present in the Evertor tablets. Some anaphylactic reaction occurs.
Pregnancy and lactation
Pregnancy category of Everolimus In patients Evertor is used only after knowing the benefits to the mother exceed the risk to the fetus. Breastfeeding should not be suggested.
Storage and handling
Evertor tablet store at 25°C Store the medicine away from moisture, heat, and light.
Overdosage
The over dosage of Everolimus is limited If overdosage occurs patient must be provided with supportive measures. And monitor evidence of toxicity in Everolimus overdosage.
Missed Dose
In case of the missed dose, patients must consult with a medical practitioner and follow the instructions given by them. thereby missed dose should be avoided and follow the regular dosing schedule.
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