Description
Everotas 10mg consist of an active ingredient known as Everolimus which is intruded with the growth of cancer cell and the process is slowed down.Everotas 10mg tablets is not a curable medication, which helps to slow their spreading into the body.
Indication
Primarily Everotas 10mg tablets indicated for the treatment* kidney carcinoma
* Breast carcinoma
* Brain carcinoma
Everolimus is also indicated in various advanced stage cancer in stomach, intestines or pancreas.
Mechanism
Everolimus is an inhibitor of mTOR, joins at high compatibility to FK506 binding protein 12, via producing drug complex that inhibits the production of mTOR. This inhibition reduces the activity of effectors downstream, which may lead to stoppage of cell progression from G1 into S phase, finally causes cell growth arrest and apoptosisDosage and administration
Everotas 10mg tablets should be given with or without food.Dosage regimen of Everotas 10mg:
In breast cancer, renal cell cancer, pancreatic cancer, Neuroendocrine cancer:
The prescribed dosage is 10mg should be taken as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Everotas as a single dose. is 4.5mg/m2 given orally
In pediatric:
The pediatric dosage of Everotas as a single dose in the brain or intracranial tumor is 4.5mg/m2 should be given orally.
Side Effects
Hypersensitivity reactions, Lymphomas & other malignancy, Serious infections, Kidney graft thrombosis, Hepatic artery thrombosis, Nephrotoxicity, Hyperlipemia, Angioedema, Interstitial lung disease, Thrombocytopenia, Male infertility, Proteinuria, New commencement of diabetes.Drug interaction
Everotas 10mg interaction with strong inhibitor of CYP3A4, or P-g p, cause reducing the efflux of Everolimus and high plasma concentration of Everolimus.Interaction of Everotas 10mg with strong CYP3A4 inducers will increase the disclosure of Everolimus.
Combination of Everotas 10mg with cyclosporine will be increasing the AUC level of Everolimus frequently.
Combination ketoconazole with Everotas 10mg tablet or other CYP3A4 inhibitors will increase the plasma concentration and AUC of Everolimus.
Pregnancy and lactation
Pregnancy category of Everolimus CIn patients, Everotas 10mg is used only after knowing the benefits to the mother exceed the risk to the fetus.
Breastfeeding should not be suggested
Storage
Everotas 10mg tablet store at 25°C.Store the medicine away from moisture, heat, and light
Missed Dose
In the case of the missed dose, patients must consult with the medical practitioner and follow the instructions given by them. Thereby missed dose should be avoided and follow the regular dosing schedule.FOR MORE INFORMATION:
EMAIL:
applepharmaceutical@gmail.com
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