Description
Evertor consist of an active ingredient known as Everolimus which is intruded with the growth of cancer cell and the process is slowed down. Evertor tablets is not a curable medication, which helps to slow their spreading into the body.Indication of Evertor
Primarily Evertor tablets indicated for the treatment :kidney carcinoma
Breast carcinoma
Brain carcinoma
Everolimus is also indicated in various advanced stage cancer in stomach, intestines or pancreas.
Mechanism
Everolimus is an inhibitor of mTOR, joins at high compatibility to FK506 binding protein 12, via producing drug complex that inhibits the production of mTOR. This inhibition reduces the activity of effectors downstream, which may lead to stoppage of cell progression from G1 into S phase, Finally causes cell growth arrest and apoptosisDosage regimen of Evertor
In breast cancer, renal cell cancer, pancreatic cancer, Neuroendocrine cancer:The prescribed dosage is 10mg should be taken as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Evertor as a single dose. is 4.5mg/m2 given orally
In pediatric:
The pediatric dosage of Evertor as a single dose in the brain or intracranial tumor is 4.5mg/m2 should be given orally.
Side Effects
Hypersensitivity reactions, Lymphomas & other malignancy, Serious infections, Kidney graft thrombosis, Hepatic artery thrombosis, Nephrotoxicity, Hyperlipemia, Angioedema, Interstitial lung disease, Thrombocytopenia, Male infertility, Proteinuria, New commencement of diabetes.Drug-Drug interaction
Evertor interaction with strong inhibitor of CYP3A4, or P-gp, cause reducing the efflux of Everolimus and high plasma concentration of Everolimus. Interaction of Evertor with strong CYP3A4 inducers will increase the disclosure of Everolimus. Combination of Evertor with cyclosporine will increase the AUC level of Everolimus frequently. Combination ketoconazole with Evertor tablet or other CYP3A4 inhibitors will increase the plasma concentration and AUC of Everolimus.Pregnancy and lactation
Pregnancy category of Everolimus In patients Evertor is used only after knowing the benefits to the mother exceed the risk to the fetus. Breastfeeding should not be suggestedStorage and handling
Evertor tablet store at 25°C Store the medicine away from moisture, heat, and lightMissed Dose
In the case of the missed dose, patients must consult with the medical practitioner and follow the instructions given by them. thereby missed dose should be avoided and follow the regular dosing schedule.FOR MORE INFORMATION:
EMAIL:
applepharmaceutical@gmail.com
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