Evertor 5mg tablet - Everolimus | Apple Pharmaceuticals

Description

Evertor 5mg consists of an active ingredient known as Everolimus which is intruded with the growth of cancer cell and process is slowed down.
Evertor 5mg tablets is not a curable medication, which helps to slow their spreading into the body.

Indication

 Primarily Evertor 5mg tablets indicated for the treatment :
* kidney carcinoma
* Breast carcinoma
* Brain carcinoma
Everolimus is also indicated in various advanced stage cancer in stomach, intestines or pancreas.

Mechanism

Everolimus is an inhibitor of mTOR, joins at high compatibility to FK506 binding protein 12, via producing drug complex that inhibits the production of mTOR.
This inhibition reduces the activity of effectors downstream, which may lead to stoppage of cell progression from G1 into S phase, Finally causes cell growth arrest and apoptosis

Dosage and administration

Evertor 5mg tablets should be given with or without food.
Dosage regimen of Evertor 5mg;
In breast cancer, renal cell cancer, pancreatic cancer, Neuroendocrine cancer:
The prescribed dosage is 10mg should be taken as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Evertor as a single dose. is 4.5mg/m2 given orally
In pediatric:
The pediatric dosage of Evertor as a single dose in the brain or intracranial tumor is 4.5mg/m2 should be given orally.

side effects

Hypersensitivity reactions, Lymphomas & other malignancy, Serious infections, Kidney graft thrombosis, Hepatic artery thrombosis, Nephrotoxicity, Hyperlipemia, Angioedema, Interstitial lung disease, Thrombocytopenia, Male infertility, Proteinuria, New commencement of diabetes.

Drug interaction

Evertor 5mg interaction with strong inhibitor of CYP3A4, or P-g p, cause reducing the efflux of Everolimus and high plasma concentration of Everolimus.
Interaction of Evertor 5mg with strong CYP3A4 inducers will increase the disclosure of Everolimus.
Combination of Evertor 5mg with cyclosporine will be increasing the AUC level of Everolimus frequently.
Combination ketoconazole with Evertor 5mg tablet or other CYP3A4 inhibitors will increase the plasma concentration and AUC of Everolimus. Concomitant use of Evertor 5mg with verapamil leads to increasing the plasma concentration of Everolimus.

Storage

Evertor 5mg tablet store at 25°C
Store the medicine away from moisture, heat, and light

Missed Dose

The over dosage of Everolimus is limited If overdosage occurs patient must be provided with supportive measures. And monitor evidence of toxicity in Everolimus overdosage

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