Description
Eltrombopag is an oral tablet which is available as the brand-name drug Revolade 25mg. The drug is not available as a generic drug.
Revolade 25mg is a prescription drug which is used under the guidance of the doctor.
Revolade 25mg drug may be used as part of combination therapy. Thereby drug may need to take it with other medications.
Indication
Revolade 25mg is mainly indicated for the treatment of patients having :
• Reduced platelet levels due to chronic immune thrombocytopenia
• Reduced platelet counts due to chronic hepatitis C virus infection
• Severe Aplastic Anemia :
• First line treatment of severe Aplastic Anemia
• Treatment of refractory severe Aplastic Anemia.
Mechanism Of Action
Revolade is part of a class of drugs called thrombopoietin (TPO) receptor agonists. Classification of drugs is an association of medications which work in a similar way. These drugs are often used to treat similar conditions. Revolade works by raise cells in bone marrow and leads these cells to make various platelets. This effect reduces the risk of bleeding.
Dosage and administration
Chronic Immune Thrombocytopenia:
Indicated only in patients with chronic immune thrombocytopenia whose clinical condition increases bleeding risk
Initial:
50 mg PO qDay
Adjust dose to achieve and control platelet count (Plt) >50 x 10^9/L to lowers risk of bleeding; not to exceed 75 mg/day
Chronic Hepatitis C-associated Thrombocytopenia
Initial:
25 mg PO qDay
Dose is Adjust in 25 mg accretion q2weeks PRN to attain target Pelt needed to start/control antiviral therapy with pegylated interferon and ribavirin; not to exceed 100 mg/day
During antiviral therapy, regulate dose to stop dose reductions of peginterferon
Severe Aplastic Anemia
Precautions
The drug causes warning condition, call the doctor while new medication interaction
Disease progression warning: Avoid using the drug while the patients have myelodysplastic syndrome (MDS), will increase the risk of death.
If other blood clot risk factors, then avoid the drug because it will increase platelet counts and blood clots.
If the patients have cataracts, avoid the drug due to the drug effects cataracts and make the condition worse.
Drug Interaction
Revolade 25mg interaction with these drugs ezetimibe, glyburide, Olmesartan, repaglinide, valsartan, imatinib, irinotecan, lapatinib, methotrexate, mitoxantrone, Bosentan, sulfasalazine, and topotecan irinotecan leads an increase of side effects. hence the doctor may reduce your dosage of these drugs if required.
Pregnancy
Pregnancy category is C
Use the Revolade 25mg with caution if asset outweighs risks. Animal studies reveal risk and human studies not available or neither animal nor human studies done.
Serious Side Effects
• Urine in dark color
• Yellowing of your skin
• Abdomen swelling
• Confusion
• Chest pain
• Dyspnea
• Cloudy vision
• Sensitivity to light
• Seeing circles around lights
• Swelling of legs.
Missed Dose
In case of a missed dose, patients must consult with a medical practitioner and follow the instructions given by them. thereby missed dose should be avoided and follow the regular dosing schedule.
Storage
Store at room temperature 20°C to 25°C.
Discard the left-out medicine if not used within 30 minutes
FOR MORE INFORMATION:
EMAIL:
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